Preprints:

Guang Yang, Ethan Parker, Bushra Gorsi, Mark Liebowitz, Colin Maguire, Jace B. King, Hilary Coon, Melissa Lopez-Larson, Jeffrey Anderson, Mark Yandell, Alex Shcheglovitov “Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder” 2022, MedRxiv

Prints:

  1. Kubanek, J, Wilson, M, Rabbitt, RD, Armstrong, CJ, Farley, AJ, Ullah, HMA et al.. Stem cell-derived brain organoids for controlled studies of transcranial neuromodulation. Heliyon. 2023;9 (8):e18482. doi: 10.1016/j.heliyon.2023.e18482. PubMed PMID:37576248 PubMed Central PMC10412769.
  2. Yang, G, Ullah, HMA, Parker, E, Gorsi, B, Libowitz, M, Maguire, C et al.. Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder. Mol Psychiatry. 2023;28 (6):2525-2539. doi: 10.1038/s41380-023-02035-w. PubMed PMID:37032361 .
  3. Wang, Y, Chiola, S, Yang, G, Russell, C, Armstrong, CJ, Wu, Y et al.. Modeling human telencephalic development and autism-associated SHANK3 deficiency using organoids generated from single neural rosettes. Nat Commun. 2022;13 (1):5688. doi: 10.1038/s41467-022-33364-z. PubMed PMID:36202854 PubMed Central PMC9537523.
  4. Shcheglovitov, A, Peterson, RT. Screening Platforms for Genetic Epilepsies-Zebrafish, iPSC-Derived Neurons, and Organoids. Neurotherapeutics. 2021;18 (3):1478-1489. doi: 10.1007/s13311-021-01115-5. PubMed PMID:34595731 PubMed Central PMC8608971.
  5. Santos, AC, Chiola, S, Yang, G, Shcheglovitov, A, Park, S. Secreted Reporter Assay Enables Quantitative and Longitudinal Monitoring of Neuronal Activity. eNeuro. 2021;8 (5):. doi: 10.1523/ENEURO.0518-20.2021. PubMed PMID:34531280 PubMed Central PMC8489021.
  6. Chiola, S, Edgar, NU, Shcheglovitov, A. iPSC toolbox for understanding and repairing disrupted brain circuits in autism. Mol Psychiatry. 2022;27 (1):249-258. doi: 10.1038/s41380-021-01288-7. PubMed PMID:34497379 PubMed Central PMC8901782.
  7. Chiola, S, Napan, KL, Wang, Y, Lazarenko, RM, Armstrong, CJ, Cui, J et al.. Defective AMPA-mediated synaptic transmission and morphology in human neurons with hemizygous SHANK3 deletion engrafted in mouse prefrontal cortex. Mol Psychiatry. 2021;26 (9):4670-4686. doi: 10.1038/s41380-021-01023-2. PubMed PMID:33558651 PubMed Central PMC8349370.
  8. Yang, G, Shcheglovitov, A. Probing disrupted neurodevelopment in autism using human stem cell-derived neurons and organoids: An outlook into future diagnostics and drug development. Dev Dyn. 2020;249 (1):6-33. doi: 10.1002/dvdy.100. PubMed PMID:31398277 PubMed Central PMC7781093.
  9. Shcheglovitov, A, Rao, M, Yoo, A. Special issue on stem cell and tissue engineering in development, disease, and repair. Dev Dyn. 2019;248 (1):7-9. doi: 10.1002/dvdy.3. PubMed PMID:30444282 .
  10. Mitz, AR, Philyaw, TJ, Boccuto, L, Shcheglovitov, A, Sarasua, SM, Kaufmann, WE et al.. Identification of 22q13 genes most likely to contribute to Phelan McDermid syndrome. Eur J Hum Genet. 2018;26 (3):293-302. doi: 10.1038/s41431-017-0042-x. PubMed PMID:29358616 PubMed Central PMC5838980.
  11. Byers, B, Lee, HJ, Liu, J, Weitz, AJ, Lin, P, Zhang, P et al.. Direct in vivo assessment of human stem cell graft-host neural circuits. Neuroimage. 2015;114 :328-37. doi: 10.1016/j.neuroimage.2015.03.079. PubMed PMID:25936696 PubMed Central PMC5573170.
  12. Eckle, VS, Shcheglovitov, A, Vitko, I, Dey, D, Yap, CC, Winckler, B et al.. Mechanisms by which a CACNA1H mutation in epilepsy patients increases seizure susceptibility. J Physiol. 2014;592 (4):795-809. doi: 10.1113/jphysiol.2013.264176. PubMed PMID:24277868 PubMed Central PMC3934715.
  13. Shcheglovitov, A, Shcheglovitova, O, Yazawa, M, Portmann, T, Shu, R, Sebastiano, V et al.. SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. Nature. 2013;503 (7475):267-71. doi: 10.1038/nature12618. PubMed PMID:24132240 PubMed Central PMC5559273.
  14. Krey, JF, Paşca, SP, Shcheglovitov, A, Yazawa, M, Schwemberger, R, Rasmusson, R et al.. Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons. Nat Neurosci. 2013;16 (2):201-9. doi: 10.1038/nn.3307. PubMed PMID:23313911 PubMed Central PMC3568452.
  15. Shcheglovitov, A, Vitko, I, Lazarenko, RM, Orestes, P, Todorovic, SM, Perez-Reyes, E et al.. Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels. J Gen Physiol. 2012;139 (3):219-34. doi: 10.1085/jgp.201110699. PubMed PMID:22371363 PubMed Central PMC3289959.
  16. Paşca, SP, Portmann, T, Voineagu, I, Yazawa, M, Shcheglovitov, A, Paşca, AM et al.. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nat Med. 2011;17 (12):1657-62. doi: 10.1038/nm.2576. PubMed PMID:22120178 PubMed Central PMC3517299.
  17. Yoo, AS, Sun, AX, Li, L, Shcheglovitov, A, Portmann, T, Li, Y et al.. MicroRNA-mediated conversion of human fibroblasts to neurons. Nature. 2011;476 (7359):228-31. doi: 10.1038/nature10323. PubMed PMID:21753754 PubMed Central PMC3348862.
  18. Nguyen, HN, Byers, B, Cord, B, Shcheglovitov, A, Byrne, J, Gujar, P et al.. LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell. 2011;8 (3):267-80. doi: 10.1016/j.stem.2011.01.013. PubMed PMID:21362567 PubMed Central PMC3578553.
  19. Park, CY, Shcheglovitov, A, Dolmetsch, R. The CRAC channel activator STIM1 binds and inhibits L-type voltage-gated calcium channels. Science. 2010;330 (6000):101-5. doi: 10.1126/science.1191027. PubMed PMID:20929812 .
  20. Vitko, I, Shcheglovitov, A, Baumgart, JP, Arias-Olguín, II, Murbartián, J, Arias, JM et al.. Orientation of the calcium channel beta relative to the alpha(1)2.2 subunit is critical for its regulation of channel activity. PLoS One. 2008;3 (10):e3560. doi: 10.1371/journal.pone.0003560. PubMed PMID:18958281 PubMed Central PMC2570331.
  21. Shcheglovitov, A, Vitko, I, Bidaud, I, Baumgart, JP, Navarro-Gonzalez, MF, Grayson, TH et al.. Alternative splicing within the I-II loop controls surface expression of T-type Ca(v)3.1 calcium channels. FEBS Lett. 2008;582 (27):3765-70. doi: 10.1016/j.febslet.2008.10.013. PubMed PMID:18930057 PubMed Central PMC2614674.
  22. Shcheglovitov, A, Kostyuk, P, Shuba, Y. Selectivity signatures of three isoforms of recombinant T-type Ca2+ channels. Biochim Biophys Acta. 2007;1768 (6):1406-19. doi: 10.1016/j.bbamem.2007.02.017. PubMed PMID:17400181 .
  23. Shcheglovitov, A, Zhelay, T, Vitko, Y, Osipenko, V, Perez-Reyes, E, Kostyuk, P et al.. Contrasting the effects of nifedipine on subtypes of endogenous and recombinant T-type Ca2+ channels. Biochem Pharmacol. 2005;69 (5):841-54. doi: 10.1016/j.bcp.2004.11.024. PubMed PMID:15710361 .
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